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Tobin, Nicole Maas-Szabowski, Christoph Peters; The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.
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D Cell surface receptor-bound 125I-EGF releasable by incubation at pH 3.
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The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling

It has also been shown that EGF is degraded in hepatocytes by cathepsin B, which is another representative of the papain-like cysteine peptidases.
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Mesenchymal-epidermal interactions assessed by heterologous organotypic co-cultures OTC.
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Monoclonal anti-mouse EGFR non-phospho-Y1173 antibody Upstate, Lake Placid, NY; at 1:1000 dilution and mouse monoclonal anti-mouse actin antibody ICN Biochemicals, Aurora, OH; at 1:2500 dilution were used.
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Since the K14-promoter directs expression to keratinocytes of the basal epidermal layer as well as to the outer root sheath of hair follicles , these data provide strong evidence that the keratinocyte represents the cell type in which CTSL is critically important for homeostasis of mouse epidermis and hair cycling.
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The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling

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The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling

Therefore, in keratinocyte cultures it is present only in minor amounts, these being derived from the fetal calf serum, which is essential for the cultivation of primary mouse keratinocytes.